MAC has several meanings, including:
- MAC (cosmetics)
- (erroneously) Macintosh computer by Apple
- Maximum Allowable Concentration of toxins, e.g. in food or as reference in environmental remediation
- mandatory access control
- Media Access Control - hence MAC address
- Message Authentication Code, in cryptography
- Metropolitan Airports Commission, operator of airports in the Minneapolis-St. Paul region of Minnesota.
- Mid-American Conference, US collegiate sports conference
- Middle Atlantic Conference, US collegiate sports conference, also its parent group, the Middle Atlantic Corporation
- The Midlands Arts Centre, a venue in Birmingham, England
- Minimum alveolar concentration (Anaesthesia)
- Michigan Agricultural College, usually written "M.A.C.", was the name of Michigan State University from 1909 to 1925.
- Multiply-accumulate, especially in digital signal processor contexts