MRSA, or methicillin-resistant Staphylococcus aureus is a bacterium that has developed antibiotic resistance, first to penicillin in 1947, and later to methicillin. Popularly termed a "superbug", it was first discovered in Britain in 1961 and is now widespread. While an MRSA colonisation in an otherwise healthy individual is not usually a serious matter, infection with the organism can be life-threatening to patients with deep wounds, intravenous catheters or other foreign-body instrumentation; or as a secondary infection in patients with compromised immune systems.
In the USA there are increasing reports of outbreaks of MRSA colonisation through skin contact in locker rooms and gymnasiums, even among healthy populations, and MRSA causes as many as 20% of Staph aureus infections in populations that use intravenous drugs.
A last-resort antibiotic, Vancomycin, is used to kill MRSA but several new strains of the bacterium (since the first report in 1997) has been found showing resistance to Vancomycin; those new evolutions of the MRSA bateria are dubbed Vacomycin-intermediate Staphylococcus aureus (VISA).
From the US CDC's MRSA Fact Sheet:
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